Whole Blood

Clinical Indication :

Red cell replacement in acute blood loss with hypovolaemia Exchange transfusion.

Dosage :

10 ml/kg or 1 unit increases Hb by 1 gm/dl.

Storage & Shelf-life :

4 ± 20C for 35 days

Red Cell Concentrates(RCC)

Clinical Indication :

• Anemia
• Thalassaemia, Sickle Cell Anemia,
• Blood loss during surgery

Dosage :

10 ml/kg or 1 unit increases Hb by 1 gm/dl.

Storage & Shelf-life :

4 ± 20C for 35/42 days

Leuco-reduced Red Cell Concentrates (LRCC)

Clinical Indication :

• Anemia
• Thalassaemia, Sickle Cell Anemia,
• Blood loss during surgery

Dosage :

10 ml/kg or 1 unit increases Hb by 1 gm/dl.

Storage & Shelf-life :

4 ± 20C for 42 days

Platelet concentrate-Random Donor Platelet (RDP)/ Single Donor Platelet (SDP)

Clinical Indication :

• Thrombocytopenia (5-20x109/L) to prevent spontaneous bleeding
• Thrombocytopenia (< 5x109/L) with active bleeding or prior to invasive procedure
• Normal platelet count : qualitative (abnormal) platelet function.
• Preferably group compatible. However, non-group specific platelets can be given

Dosage :

• No standard dose for platelet transfusion in medical practice.
• 1 unit/10 kgs wight; 4 units/m2 surface area
• 1 plateletphresis unit increase the recipients platelet count by 20,000-40,000/mm3

Storage & Shelf-life :

22 ± 20C for 5 days

Fresh Frozen Plasma

Clinical Indication :

• Acquired bleeding disorders with active bleeding or prior to an invasive procedure. (Liver disease; Vit K Deficiency or Warfarin; disseminated intravascular coagulation-DIC; Dilutional coagulopathy)
• Hereditary bleeding disorders, when a concentrate is not available (FV or FXI deficiency)
• Special Consideration : ABO compatible, No Rh- compatibility or X- match required

Dosage :

10-15 ml/kg should be given

Storage & Shelf-life :

below -300C for 1 year

Cryoprecipitate

Clinical Indication :

• Hypofibrinogemia : fibrinogen < 100 mg/dl with active bleeding or fibrinogen < 200 mg/dl in a postoperative patient with excessive bleeding.
• Von Willebrand's disease
• Uremia or hereditary platelet disorder
• Factor XIII deficiency

Special Consideration :

No ABO, Rh or X-match required

Dosage :

1 unit/10 kg should be given

Storage & Shelf-life :

below -300C for 1 year

Saline-washed Red Cell Concentration

Wash Red cell by normal saline for removal of plasma protein substance.

Clinical Indication :

• Symptomatic anemia with plasma protein antibodies, IgA Ab.s, PNH, H/O febrile reactions

Dosage :

10 ml/kg or 1 unit to increase Hb 1gm/dl

Storage & Shelf-life :

4 ± 20C 24 hours if prepared by open system. If prepared by closed system same as original blood unit.

Exchange Transfusion Product

Clinical Indication :

Exchange transfusion is generally carried out for hyper-bilirubinaemia and / or usually due to hemolytic disease of the newborn (HDN) or prematurity. That time Red Cell Concentrate and Fresh Frozen Plasma mixture is a good choice.

RVBB & RC produces a red cell product especially for neonatal exchange transfusion.

• Group O Negative or O Positive (If mother & child both are Rh Positive)
• Leucocyte Depleted
• Fresh (< 3 days)

A Plasma Product

Group AB plasma.

Using sterile connecting devise to maintain sterility and avoid bacterial contamination.

Dosage :

Full body blood volume of the patient. Average 350-500 ml of blood.

Storage & Shelf-life :

24 hours after mixture preparation